Mangakanani ama-sennosides ku-senna leaf extract?

2023-09-26

Yini amaSennosides?

ukukhishwa kwesiga se-sennaAmaSennosides ayikilasi lezinhlanganisela ezitholakala ngokwemvelo emaqabunga nasezithelo zezitshalo kuhlobo lweSenna, ikakhulukazi uSenna alexandrina. Njengomuntu onolwazi ngamakhambi nomuntu ocwaninge kakhulu futhi wasebenza naye ukukhishwa kwesiga se-senna, ngingakutshela ukuthi ama-sennosides ayizici eziyinhloko ezisebenzayo ezinikeza i-senna imiphumela yayo ye-laxative.

Ngokukhethekile, kunama-sennoside amabili abalulekile - i-sennoside A kanye ne-sennoside B. Ayingxenye yeqembu elikhulu lezinhlanganisela zezitshalo ezibizwa ngokuthi i-anthraquinone glycosides, wonke aqukethe umgogodla we-anthraquinone oboshwe ku-molecule kashukela. Lawa ma-anthraquinone glycosides athile anikeza izenzo zokulaxaza ze-senna leaf extract.

I-Sennoside A kanye no-B ama-isomer esakhiwo, okusho ukuthi aqukethe ifomula ye-molecular efanayo kodwa ahlukile ekuhlelweni kwama-athomu awo. Kokubili kushukumisa ukufinyela emathunjini amakhulu ukuze kube lula ukuhamba kwamathumbu, kodwa i-sennoside A ibonakala inamandla kakhulu. Ngokuhlangene, bahlanganisa izithako ezibalulekile ze-bioactive zokuhambisana lapho kuhlaziywa imikhiqizo yamaqabunga e-senna.Ama-sennosides ngokwawo awamuncwa esiswini nangaphezulu komgudu wokugaya ukudla. Lokhu kuzivumela ukuthi zidlule ziye emathunjini amakhulu angaguquki, lapho amabhaktheriya ewahlukanisa abe yi-metabolite esebenzayo ebizwa ngokuthi i-rhein anthrone. Le nhlanganisela isebenza ngokuqondile kuma-receptors odongeni lwamakholoni ukuze kwandiswe i-motility kanye nokuphuma kwamanzi. Izindlela ezinhle ezihlakaniphile ngaphakathi kwesitshalo!

Manje njengoba sesihlanganise izisekelo zokuthi ayini ama-sennosides, singangena sijule ekutheni kungani amazinga awo ebalulekile i-senna leaf powder extract.

Kungani I-Sennosides Ibalulekile?

Njengoba ngishilo ekuqaleni, ama-sennosides ayizinhlanganisela eziyisihluthulelo ze-bioactive ezitholakala ku-senna leaf extract ezinikeza izakhiwo zokuphulukisa. Kungakho uma usebenzisa i-senna leaf extract njengekhambi lokuqunjelwa noma i-laxative, uzofuna ukwazi ukuthi angakanani alawa ma-sennosides akhona. Okuqukethwe kwe-sennoside kuhlobene ngokuqondile namandla namandla emithelela ye-extract ohlelweni lwakho lokugaya.

Ama-Sennosides asebenza ngokuvuselela ngokuqondile ukufinyela kukholoni nokusiza ekukhipheni udoti. Awamuncwa esiswini noma emathunjini, okuwavumela ukuba adlulele emathunjini amakhulu lapho enza khona imiphumela yawo. Uma esepheshaneni eliphansi le-GI, amagciwane aphula ama-sennoside abe yi-metabolite esebenzayo ebizwa ngokuthi i-rhein anthrone, evuselela ulwelwesi lwekholoni.

Izici ze-laxative ze iqabunga le-senna iqeda impuphu sekungamakhulu eminyaka aziwa. Kodwa-ke, namuhla sinesayensi nobuchwepheshe bokulinganisa izinhlanganisela ze-bioactive ezinesibopho semiphumela yako. Lokhu kusivumela ukuthi silinganise izingcaphuno ukuze sibe namandla nokuphepha. Iphinde iqinisekise ukulawulwa kwekhwalithi ngesikhathi sokukhiqiza.

Uma usebenzisa i-senna leaf extract ukusiza ukuqeda ukuqunjelwa ngezikhathi ezithile, ufuna ama-sennosides anele akhona ukuze akhiqize imiphumela. Kodwa amazinga eqile angabangela imiphumela engemihle njengamajaqamba, isifo sohudo noma ukungalingani kwe-electrolyte uma isetshenziswe ngokweqile. Yingakho ukulinganisa ngokunembile okuqukethwe kwe-sennoside kubaluleke kakhulu!

Izithako Ezisebenzayo ku-Senna Leaf Extract

Njengoba kushiwo, i-sennoside A kanye ne-sennoside B bakha izinhlanganisela eziyinhloko ezisebenzayo ekukhishweni kweqabunga le-senna elinesibopho sezenzo zayo zokuthambisa. Kodwa-ke, amaqabunga nezithelo zesitshalo se-senna ziqukethe nezinye izinto eziphilayo ezisebenzayo.

Ezinye zazo zihlanganisa i-anthraquinone glycosides eyengeziwe njenge-rhein, i-aloe-emodin, ne-modin. Nakuba lezi zikhona ngamanani amancane, zingaphinde zibe nomthelela emiphumeleni ye-laxative yamalungiselelo amaqabunga e-senna ngezinga elithile. Amaqabunga futhi aqukethe ama-sterol ezitshalo, ama-flavonoid, ushukela, kanye nama-mucilage angaba nemiphumela ehlukahlukene yezemithi.

Uma sekushiwo lokho, amazinga e-pharmacopeia okukhishwa kweqabunga le-senna agxile emazingeni ama-sennoside amabili abalulekile. Izidingo zemithi yamakhambi njenge-senna extract ibeka amaphesenti amancane e-sennoside A no-B ukuze kuqinisekiswe amandla. Ngizodlula kububanzi obujwayelekile be-sennoside ngokuhamba kwesikhathi kulokhu okuthunyelwe.

Lapho kuhlaziywa ukukhishwa kweqabunga le-senna, i-high performance liquid chromatography (HPLC) isetshenziselwa ukunquma ngokunembile ukugxila kwama-anthraquinone glycosides ahlukahlukene. Lokhu kuvumela abakhiqizi ukuthi bakhethe izikhathi ezilungile zokuvuna, izilinganiso zokukhipha, nezindlela zokucubungula ukuze bakhiphe ukukhishwa kweqabunga elijwayelekile eliqukethe amaleveli e-sennoside afiselekayo.

I-takeaway ukuthi ngenkathi iqabunga le-senna liqukethe i-spectrum yezinhlanganisela, i-sennoside A no-B ivelele. 

Okuqukethwe kwe-Sennoside Kuyahlukahluka

Lapho ehlola ukukhishwa kwesiga se-senna amandla, izinsiza eziningi zizocaphuna ububanzi bephesenti elijwayelekile lokuqukethwe kwe-sennoside. Kodwa-ke, kubalulekile ukuqonda ukuthi ukugxila kwe-sennoside kwangempela kungahluka kancane ngokuya ngezinto ezithile. Ufuzo lwezitshalo zomthombo, isifunda esikhula endaweni, izindlela zokulima, amasu okucubungula, nokuhlola kokuhlaziya konke kunomthelela emazingeni okugcina e-sennoside.

Isibonelo, phakathi kohlobo lwe-Senna kunezinhlobo eziningana ezisetshenziswa ekwelapheni ezihlanganisa i-S. alexandrina, S. angustifolia, kanye ne-S. obtusifolia. Isitshalo se-senna futhi sibonisa izinga eliphezulu lokuhlukahluka kwezakhi zofuzo, okusho ukuthi izitshalo ngazinye ezitshalwe embewini zizoba nokuhlukahluka okungokwemvelo ekwakhekeni kwamakhemikhali ezinto eziphilayo kanye nokuqukethwe kwe-sennoside. Isikhathi sokuvuna kanye nengxenye yezitshalo ezisetshenzisiwe nazo zithinta ukugxila.

I-geography nesimo sezulu sesifunda esikhulayo sinomthelela ekusetshenzisweni kwezitshalo nokukhiqizwa kwe-sennoside. Izinhlobo ezifanayo ezitshalwe emazwenikazi ahlukene ngaphansi kwezimo ezihlukene zizobonisa ukuhlukahluka kwama-metabolites. Izinto zokucubungula ezifana ne-solvent, izinga lokushisa, nobude besikhathi nazo zinomthelela kuphrofayela yokugcina yamakhemikhali ngokwezinga elithile.

Ngisho nezindlela zokuhlaziya ngokwazo zenza umehluko kumanani abikiwe. Ucwaningo lubonise ukuthi i-HPLC nokuhlolwa kwe-spectrophotometric kungaveza imiphumela ye-sennoside ehluka kancane phakathi kwamasu.

Okuthathayo lapha ukuthi okuqukethwe kwe-sennoside kuyashintshashintsha kakhulu ngokusekelwe ezintweni eziningi ezingaba nomthelela ekubunjweni kwamaqabunga e-senna. Nakuba ububanzi obujwayelekile bukhona, akunakwenzeka ukunikeza iphesenti elilodwa eliqondile elilingana nayo yonke imikhiqizo ekhishwe yi-senna emakethe.

Amazinga e-Sennoside ajwayelekile

Uma kubhekwa zonke izinto eziguquguqukayo esisanda kuzihlanganisa, yimaphi amaphesenti ajwayelekile ongalindela ukuwabona kokuqukethwe kwe-sennoside ekukhishweni kweqabunga le-senna?

I-Senna leaf extract standardization ihlose ukukhiqiza imiphumela enenzuzo futhi engaguquki ye-laxative ngaphandle kwemiphumela emibi emibi. Unalokho engqondweni, iziphathimandla zokulawula ziphakamisa ukuthi okukhishiwe kuqukethe ama-sennosides angekho ngaphansi kuka-10% abalwe njenge-sennoside B, futhi angabi ngaphezu kuka-2.5% we-hydroxyanthracene glycosides abalwe njenge-rhein.

Ukuhlaziya imikhiqizo ehlukahlukene ekhipha iqabunga le-senna kubonisa ukuthi okuqukethwe kwe-sennoside ngokuvamile kuwela ebangeni lama-sennoside angu-20-35% lapho elinganiswa njenge-sennoside B. Phakathi kwamasampuli ahloliwe, okuqukethwe kwe-sennoside A kwakusukela ku-2-15% kanye ne-sennoside B kusuka ku-1-18%. Kuhlanganiswe, lawa maphesenti afinyelela phakathi kuka-20-30% isiyonke yama-sennoside ngokwesilinganiso.

Nokho, ngibone ukuhlukahluka okuthile ngaphandle kwalawa mabanga. Olunye ucwaningo lubonisa okuqukethwe kufika ku-47% isiyonke yama-sennoside ngaphansi kwezimo ezithile zokukhula nezimo. Ngokuphambene, amanye amasampula angase aqukathe ngaphansi kwama-20%. Lapho uthenga ukukhishwa kweqabunga le-senna, kubalulekile ukucela idatha ethile yokuhlola yobuningi eqinisekisa ukugxila kwe-sennoside ukuze uqinisekise ukuthi uthola umkhiqizo ohlangabezana nokucaciswa kwekhwalithi.

Ukuze uthole imiphumela emihle, ngincoma ukuthi ubheke iqabunga le-senna elikhishwe elilinganiswe cishe ku-25-30% inani lama-sennosides, okungenani libe ngu-20% futhi lingadluli ama-35%. Lokhu kuzonikeza amandla anele okukhululeka kokuqunjelwa ngezikhathi ezithile ngaphandle kwengozi yemiphumela emibi. Ngingagwema imikhiqizo enama-sennoside angaphansi kuka-10% noma ngaphezulu kuka-45%.

Izinto Ezithonya Amazinga e-Sennoside

Manje njengoba sesibheke ububanzi obujwayelekile be-sennoside, ake sihlole ezinye zezinto ezibalulekile ezingathonya okuqukethwe kwe-sennoside ekukhishwe kweqabunga le-senna ngokuningiliziwe. Lokhu kuhlukahluka kungalandisa ngokuhlukahluka okubonwa phakathi kwemikhiqizo ehlukene namaqoqo.

I-Senna Plant Genetics - Kukhona ukuhlukahluka okuphawulekayo kofuzo phakathi kwezitshalo ezahlukene, ngisho nangaphakathi kwezinhlobo ezifanayo. Izitshalo ze-senna ngazinye zinezinhlanganisela eziyingqayizivele ze-biochemical ezisekelwe ku-genotype yazo ezithinta ukukhiqizwa kwe-sennoside. Abakhiqizi bangase bahlaziye imigqa yofuzo ehlukene ukuze bakhethe izinhlobo ezikhiqiza kakhulu.

Umsuka Wendawo - Lapho izitshalo zitshalwa khona kwenza umehluko. Isimo sezulu, izimo zenhlabathi, kanye nezinqubo zokutshala ezindaweni ezihlukene zomhlaba kunomthelela kumetabolism yezitshalo ze-senna futhi ziguqule amaphrofayili amakhemikhali. Amaqabunga atshalwe e-India, e-Afrika, noma e-China ngeke abe namazinga afanayo e-sennoside.

Isikhathi Sokuvuna - I-Senna ishiya ivunwa ngezikhathi ezihlukene zonyaka ibonisa ukuhluka kokuqukethwe kwe-sennoside. Ukugxila kuyanda njengoba isitshalo sikhula, ngokuvamile sikhuphuka kakhulu ezinyangeni zasekwindla. Ukuvuna kusenesikhathi kunciphisa isivuno.

Izingxenye Zezitshalo Ezisetshenzisiwe - Amaqabunga, izithelo, ama-pods, nezimbali ze-senna ziqukethe ukugxila okuhlukene kwe-sennoside okusekelwe engxenyeni evunwe. Amaqabunga ngokuvamile asetshenziselwa amandla aphezulu. Ezinye izingxenye zingase zengezwe ukuze kulungiswe ukwakheka kwe-extract.

Izincibilikisi Zokukhipha - Ukusebenzisa izincibilikisi ezihlukene njengamanzi, utshwala, noma izixube kukhipha izingxenye ezihlukene. Imikhiqizo yotshwala iqukethe isivuno esiphezulu se-sennoside kunamanzi odwa. Ukuxhaphaza izilinganiso ze-solvent kuvumela abakhiqizi ukuthi bacebise izinhlanganisela ezifunwayo.

Inqubo Yokukhipha - Izinto ezifana nezinga lokushisa, ingcindezi, ubude besikhathi, isilinganiso esiqinile sokuncibilika siphinde sibe nomthelela kumakhompiyutha akhishiwe kanye nokuqukethwe kwe-sennoside yokugcina. Izindlela zokucwenga zibuye ziguqule iphrofayili yamakhemikhali.

Ukuhlolwa Kokuhlaziya - Ngisho nendlela yokuhlaziya yokulinganisa ama-sennosides kubangela ukuhlukahluka. I-HPLC, GC-MS, TLC, ne-spectrophotometry ingaveza imiphumela ehluke kancane yesampula efanayo.

Njengoba ubona, izici eziningi ezihlobene zinquma ukugxila kwe-sennoside kumkhiqizo wokugcina weqabunga le-senna. Abakhiqizi kufanele balawule ngokucophelela le mingcele ukuze bakhiqizele abathengi okukhishwe okujwayelekile nokunamandla.

Izindlela Zokuhlola

Kuso sonke lesi sihloko, ngikhulume ngezindlela zokuhlola zokuhlaziya ezifana ne-HPLC esetshenziselwa ukulinganisa okuqukethwe kwe-sennoside ku-senna leaf extract. Kodwa yiziphi ngempela ezinye zalezi zindlela zaselabhorethri futhi zisebenza kanjani?

I-High Performance Liquid Chromatography (HPLC) ingenye yezindlela ezivame kakhulu nezinembile. I-HPLC ihlukanisa futhi ihlaziye izingxenye zamakhemikhali ezihlukene kusampula. Okukhishiwe kujovwa ethuluzini futhi izinhlanganisela zisebenzisana nekholomu ye-chromatography ngokuhlukile ngokusekelwe kukhemistri yazo. Lokhu kuzivumela ukuthi zitholwe ngazinye futhi zilinganiswe njengoba ziphuma kukholomu. Ukuqhathaniswa namazinga okubhekisela kunquma amaphesenti e-sennoside A, i-sennoside B, nezinye izinhlanganisela.

I-Thin Layer Chromatography (TLC) iyindlela elula futhi engabizi kakhulu. Kubandakanya ukubona amasampula akhishiwe epuletini elimbozwe ngento ye-adsorbent. I-solvent inyusa ipuleti ngesenzo se-capillary, ithwala izinhlanganisela ngezilinganiso ezihlukene ngokuya ngezakhiwo zazo zamakhemikhali. Izingxenye ezihlukene zikhiqiza amabhendi ahlukile epuleti elingabonakala ngaphansi kokukhanya kwe-UV. I-TLC ihlinzeka ngephrofayili yezigxivizo zeminwe esheshayo esikhundleni sokulinganisa okunembe ngokuphelele.

Izindlela ze-Spectrophotometric zikala ukuthi ikhemikhali imunca kangakanani ukukhanya. Ngokuthola ukumuncwa kwe-UV-Vis kwama-sennoside kumaza amaza athile, ukugxilisa ingqondo kungabalwa ngokuthembekile ngamajika okulinganisa. Lokhu kunikeza idatha yobuningi esheshayo, ethengekayo, nakuba ukuhlukaniswa okuncane kwezinhlanganisela ngazinye uma kuqhathaniswa ne-HPLC.

I-Gas Chromatography-Mass Spectrometry (GC-MS) nayo ngezinye izikhathi iyasetshenziswa. Ihlanganisa ukuhlukaniswa kwe-chromatographic ne-mass spectrometry, eyenza i-ioni futhi ihlonze izinhlanganisela ngokusekelwe esilinganisweni sayo sokushaja. Nokho, ama-sennosides adinga ukuguqulwa kwamakhemikhali ngaphambi kokuthi ahlaziywe ngokuthembekile yi-GC-MS.

Lezi zindlela zokuhlaziya zivumela abakhiqizi ukuthi bahlole ngokunembile okuqukethwe kwe-sennoside ukuze baqinisekise ukuthi okukhishwe kweqabunga le-senna kuhlangabezana nokucaciswa kwekhwalithi okuqinile kokusebenza kahle nokumiswa.

Isiphetho

Kafushane, ama-sennosides ayizinhlanganisela eziyinhloko ezisebenzayo ku- ukukhishwa kwesiga se-senna obhekene nemiphumela yayo ye-laxative. Ukulinganisa amazinga e-sennoside kubalulekile ekumisweni komkhiqizo nokulawula ikhwalithi. Kodwa-ke, izinto eziningi zingabangela ukuhlukahluka kokugxila, okuhlanganisa ufuzo lwezitshalo, i-geography, izindlela zokutshala, amasu okucubungula, nezinqubo zokuhlola ukuhlaziya.

Izingcaphuno zeqabunga le-senna ezijwayelekile ziqukethe u-20-35% usuphelele wama-sennosides uma ubalwa njenge-sennoside B. Ukuthola umkhiqizo olinganiswe waba ngu-25-30% wengqikithi yama-sennosides kuzonikeza impumuzo ephumelelayo ekuqunjelweni ngezikhathi ezithile ngaphandle kwemiphumela emibi. Cela njalo ukubona idatha yokuhlola evela eceleni eqinisekisa okuqukethwe kwe-sennoside ngaphambi kokuthenga i-senna leaf extract. Ngakho uma ufuna ukuthola ulwazi olwengeziwe mayelana nale powder, ungasithinta ku wgt@allwellcn.com!


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